Kitasamycin

Names

[ Name ]:
Kitasamycin

[Synonym ]:
(2S,3S,4R,6S)-6-{[(2R,3S,4R,5R,6S)-6-{[(4R,5S,6S,7R,9R,10R,11E,13E,16R)-4,10-Dihydroxy-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)oxacyclohexadeca-11,13-dien-6-yl]oxy}-4-(dimethylamino)-5-hydroxy-2-methyltetrahydro-2H-pyran-3-yl]oxy}-4-hydroxy-2,4-dimethyltetrahydro-2H-pyran-3-yl 3-methylbutanoate (non-preferred name)
Ayermycin
3-Deacetyljosamycin
Sineptina
Syneptine
(2S,3S,4R,6S)-6-{[(2R,3S,4R,5R,6S)-6-{[(4R,5S,6S,7R,9R,10R,11E,13E,16R)-4,10-Dihydroxy-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)oxacyclohexadeca-11,13-dien-6-yl]oxy}-4-(dimethylamino)-5-hydroxy-2-methyltetrahydro-2H-pyran-3-yl]oxy}-4-hydroxy-2,4-dimethyltetrahydro-2H-pyran-3-yl 3-methylbutanoate
EINECS 232-429-6
3-O-Deacetyljosamycin
Kitasamycin
Leucomycin A1
Stereomycine

Biological Activity

[Description]:

Leucomycin (kitasamycin) is a macrolide antibiotic produced by Streptomyces kitasatoensis[1][2][3][4].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. PACHTMAN EA, et al. Leucomycin; a new antibiotic. Am J Pharm Sci Support Public Health. 1958 Oct;130(10):342-4.

[2]. Vézina C, et al. Biosynthesis of kitasamycin (leucomycin) by leucine analog-resistant mutants of Streptomyces kitasatoensis. Antimicrob Agents Chemother. 1979 May;15(5):738-46.

[3]. La T, et al. Testing the efficacy of kitasamycin for use in the control and treatment of swine dysentery in experimentally infected pigs. Aust Vet J. 2019 Sep 17.

[4]. Hassan AB, et al. Pharmacokinetics and tissue residues of kitasamycin in healthy and diseased broilers. Dtsch Tierarztl Wochenschr. 1990 Aug;97(8):315-7.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
874.7±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₄₀H₆₇NO₁₄

[ Molecular Weight ]:
785.958

[ Flash Point ]:
482.8±34.3 °C

[ Exact Mass ]:
785.456177

[ LogP ]:
3.35

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.541

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
ethanol: 50 mg/mL, clear to slightly hazy, light-yellow

Safety Information

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
24/25

[ WGK Germany ]:
1

[ RTECS ]:
WG9400000

Related Compounds

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