Me1111

ME1111 is an antifungal agent that is active against dermatophytes. ME1111 is an inhibitor of the succinate dehydrogenase of Trichophyton species. ME1111 has an excellent ability to penetrate human nails and is used for onychomycosis research[1][2].

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Fungal

dermatophytes[1]

ME1111 inhibits T. mentagrophytes TIMM 2789, with MICs of 0.5 μg/mL and 0.25 μg/mL in RPMI 1640 medium and SDB, respectively[1]. ME1111 mainly affects the permeability of the cell membrane[1]. ME1111 strongly inhibits the succinate-2,6-dichlorophenolindophenol reductase reaction in Trichophyton rubrum and T. mentagrophytes (IC50: 0.029 μg/mL, 0.025 μg/mL) but only shows moderate inhibition of the same reaction in human cell lines[2]. Cell Viability Assay[1] Cell Line: T. mentagrophytes TIMM 2789 Concentration: 0.125 μg/mL, 0.0625 μg/mL Incubation Time: 4 hours, 8 hours, 24 hours Result: Inhibited the hyphal growth in a dose-dependent and time-dependent manner, and induced various morphological alterations.

[1]. Nishiyama Y, et al. Morphological Effect of the New Antifungal Agent ME1111 on Hyphal Growth of Trichophyton mentagrophytes, Determined by Scanning and Transmission Electron Microscopy. Antimicrob Agents Chemother. 2016 Dec 27;61(1).

[2]. Takahata S, et al. Mechanism of Action of ME1111, a Novel Antifungal Agent for Topical Treatment of Onychomycosis. Antimicrob Agents Chemother. 2015 Nov 23;60(2):873-80.