Landogrozumab

Names

[ Name ]:
Landogrozumab

Biological Activity

[Description]:

Landogrozumab (LY2495655) is an humanized anti-myostatin monoclonal antibody. Landogrozumab effectively improves muscle volume, hand grip strength and function. Landogrozumab can be used for the research of muscle wasting disease[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[In Vivo]

Landogrozumab (3 和 15 mg/kg；静脉注射 1 次) 影响杜氏肌营养不良老年小鼠的肌肉质量[1]。 Animal Model: Duchenne muscular dystrophy (DMD) C57BL/10-mdx mouse model[1] Dosage: 3 and 50 mg/kg Administration: Intravenous injection; 3 and 50 mg/kg once Result: Increasesd muscle mass of aged mice at a dose of 50 mg/kg while 3 mg/kg showed no significant effects.

[References]

[1]. Muramatsu H, et al. Novel myostatin-specific antibody enhances muscle strength in muscle disease models. Sci Rep. 2021 Jan 25;11(1):2160.

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds

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