Uralenol

Names

[ Name ]:
Uralenol

[Synonym ]:
Uralenol
3,5,7,3',4'-Pentahydroxy-5'-isoprenylflavone

Biological Activity

[Description]:

Uralenol is a natural PTP1B inhibitor (IC50=21. 5 μM) from Broussonetia papyrifera. PTP1B have been shown to play a major role in the dephosphorylation of the insulin receptor in many cellular and biochemical studies[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase

Research Areas >> Metabolic Disease

[References]

[1]. Chen RM, et al. Natural PTP1B inhibitors from Broussonetia papyrifera. Bioorg Med Chem Lett. 2002;12(23):3387-3390.

Chemical & Physical Properties

[ Density]:
1.519g/cm3

[ Boiling Point ]:
654.1ºC at 760 mmHg

[ Molecular Formula ]:
C₂₀H₁₈O₇

[ Molecular Weight ]:
370.35300

[ Flash Point ]:
236.6ºC

[ Exact Mass ]:
370.10500

[ PSA ]:
131.36000

[ LogP ]:
3.49670

[ Vapour Pressure ]:
1.04E-17mmHg at 25°C

[ Index of Refraction ]:
1.723

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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