25CN-NBOH

Names

[ Name ]:
25CN-NBOH

[Synonym ]:
Benzonitrile, 4-[2-[[(2-hydroxyphenyl)methyl]amino]ethyl]-2,5-dimethoxy-
25CN-NBOH
4-{2-[(2-Hydroxybenzyl)amino]ethyl}-2,5-dimethoxybenzonitrile

Biological Activity

[Description]:

A potent, highly selective and brain-penetrant 5-HT2A receptor agonist with Ki of 1.1 nM ([3H]ketanserin); >100-fold over 5-HT2CR and 46-fold selectivity over 5-HT2BR; exhibits 30- to 180-fold 5-HT2A/5-HT2C selectivities and 54-fold 5-HT2A/5-HT2B selectivity in inositol phosphate and intracellular Ca2+ mobilization assays; is a superior selective and brain-penetrant 5-HT2A receptor agonist compared with (±)-2,5-dimethoxy-4-iodoamphetamine (DOI).

[References]

References 1. Jensen AA, et al. J Pharmacol Exp Ther. 2017 Jun;361(3):441-453. 2. Fantegrossi WE, et al. Psychopharmacology (Berl). 2015 Mar;232(6):1039-47. 3. Halberstadt AL, et al. Neuropharmacology. 2016 Aug;107:364-375. 4. Hansen M, et al. ACS Chem Neurosci. 2014 Mar 19;5(3):243-9. View Related Products by Target 5-HT Receptor

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
508.5±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₈H₂₀N₂O₃

[ Molecular Weight ]:
312.363

[ Flash Point ]:
261.3±30.1 °C

[ Exact Mass ]:
312.147400

[ LogP ]:
2.33

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.597

Related Compounds

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