1-(2-chloroethyl)-1-nitroso-3-(2-norb-ornyl)urea
Names
[ CAS No. ]:
13909-13-2
[ Name ]:
1-(2-chloroethyl)-1-nitroso-3-(2-norb-ornyl)urea
Chemical & Physical Properties
[ Density]:
1.52g/cm3
[ Molecular Formula ]:
C10H16ClN3O2
[ Molecular Weight ]:
245.70600
[ Exact Mass ]:
245.09300
[ PSA ]:
61.77000
[ LogP ]:
2.49770
[ Index of Refraction ]:
1.668
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- YS5075000
- CHEMICAL NAME :
- Urea, 1-(2-chloroethyl)-1-nitroso-3-(2-norbornyl)-
- CAS REGISTRY NUMBER :
- 13909-13-2
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C10-H16-Cl-N3-O2
- MOLECULAR WEIGHT :
- 245.74
- WISWESSER LINE NOTATION :
- L55 ATJ CMVNNO&2G
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 83 mg/kg
- TOXIC EFFECTS :
- Liver - jaundice, other or unclassified Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- NCIMR* Progress Report Submitted to the National Cancer Institute by Mason Research Institute. (Worcester, MA) Volume(issue)/page/year: -,372,1968
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 56 mg/kg
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- NCIMR* Progress Report Submitted to the National Cancer Institute by Mason Research Institute. (Worcester, MA) Volume(issue)/page/year: -,372,1968
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 54760 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 18750 ug/kg/15D-I
- TOXIC EFFECTS :
- Blood - normocytic anemia Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
- REFERENCE :
- NCIMR* Progress Report Submitted to the National Cancer Institute by Mason Research Institute. (Worcester, MA) Volume(issue)/page/year: -,372,1968
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 15 mg/kg/5W-I
- TOXIC EFFECTS :
- Liver - change in gall bladder structure or function Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
- REFERENCE :
- NCIMR* Progress Report Submitted to the National Cancer Institute by Mason Research Institute. (Worcester, MA) Volume(issue)/page/year: -,372,1968
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Primate - monkey
- DOSE/DURATION :
- 35 mg/kg/15D-I
- TOXIC EFFECTS :
- Liver - fatty liver degeneration Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- NCIMR* Progress Report Submitted to the National Cancer Institute by Mason Research Institute. (Worcester, MA) Volume(issue)/page/year: -,372,1968
Safety Information
[ HS Code ]:
2924299090
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2924299090
[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%