CT-721

Names

[ CAS No. ]:
1388710-60-8

[ Name ]:
CT-721

Biological Activity

[Description]:

CT-721 is a potent and time-dependent Bcr-Abl kinase inhibitor with an IC50 of 21.3 nM for wild-type Bcr-Abl kinase, and possesses anti-chronic myeloid leukemia (CML) activities[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Bcr-Abl

[Target]

IC50: 21.3 nM (wild-type Bcr-Abl kinase)[1]


[References]

[1]. Sun Y, et al. CT-721, a Potent Bcr-Abl Inhibitor, Exhibits Excellent In Vitro and In Vivo Efficacy in the Treatment of Chronic Myeloid Leukemia. J Cancer. 2017 Aug 23;8(14):2774-2784.

Chemical & Physical Properties

[ Molecular Formula ]:
C30H29ClN6O

[ Molecular Weight ]:
525.04

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds