Factor D inhibitor 6

Factor D inhibitor 6 is a potent and selective, orally bioavailable inhibitor of Factor D with IC50 of 30 nM; is highly selective for human FD, showing no inhibition of factor B; efficiently block alternative pathway activation and prevent both C3 deposition onto, and lysis of, PNH erythrocytes; inhibits lipopolysaccharide-induced AP activation in FD-humanized mice.

References 1. Maibaum J, et al. Nat Chem Biol. 2016 Dec;12(12):1105-1110. View Related Products by Target Complement System