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Tormentic acid

Names

[ CAS No. ]:
13850-16-3

[ Name ]:
Tormentic acid

[Synonym ]:
Urs-12-en-28-oic acid, 2,3,19-trihydroxy-, (2α,3β)-
Jacarandic acid
tomentic acid
Tormentic acid
(2α,3β)-2,3,19-Trihydroxyurs-12-en-28-oic acid
Euscaphic acid
2,3,19-trihydroxyurs-12-en-28-oic acid

Biological Activity

[Description]:

Tormentic acid, a triterpene isolated from Rosa rugosa, exerts anti-inflammatory, antihyperlipidemic, and anti-atherogenic properties[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> Others >> Others
Research Areas >> Inflammation/Immunology

[In Vitro]

Tormentic acid inhibits LPS-induced iNOS, COX-2, and TNF-α expression through inactivation of the nuclear factor-κb pathway in RAW 264.7 macrophages[1]. Tormentic acid suppresses high-fat diet-induced diabetes and hyperlipidemia by glucose transporter 4 and AMP-activated protein kinase phosphorylation[2].

[References]

[1]. An HJ, et al. Tormentic acid, a triterpenoid saponin, isolated from Rosa rugosa, inhibited LPS-induced iNOS, COX-2, and TNF-α expression through inactivation of the nuclear factor-κb pathway in RAW 264.7 macrophages. Int Immunopharmacol. 2011 Apr;11(4):504-10.

[2]. Wu JB, et al. Tormentic acid, a major component of suspension cells of Eriobotrya japonica, suppresses high-fat diet-induced diabetes and hyperlipidemia by glucose transporter 4 and AMP-activated protein kinase phosphorylation. J Agric Food Chem. 2014 Nov 5;62(44):10717-26.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
602.7±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C30H48O5

[ Molecular Weight ]:
488.699

[ Flash Point ]:
332.3±28.0 °C

[ Exact Mass ]:
488.350189

[ PSA ]:
97.99000

[ LogP ]:
6.21

[ Vapour Pressure ]:
0.0±3.9 mmHg at 25°C

[ Index of Refraction ]:
1.580

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds