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Carmoterol hydrochloride

Names

[ CAS No. ]:
137888-11-0

[ Name ]:
Carmoterol hydrochloride

[Synonym ]:
8-Hydroxy-5-((1R)-1-hydroxy-2-(N-(1R)-2-(p-methoxyphenyl)isopropylamino)ethyl)carbostyril HCl
8-Hydroxy-5-[(1R)-1-hydroxy-2-{[(2R)-1-(4-methoxyphenyl)-2-propanyl]amino}ethyl]-2(1H)-quinolinone hydrochloride (1:1)
Carmoterol hydrochloride
8-hydroxy-5-[(1R)-1-hydroxy-2-{[(2R)-1-(4-methoxyphenyl)propan-2-yl]amino}ethyl]-1,2-dihydroquinolin-2-one hydrochloride
2(1H)-Quinolinone, 8-hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]-, hydrochloride (1:1)
8-Hydroxy-5-(1-hydroxy-2-(N-(2-(4-methoxyphenyl)-1-methylethyl)amino)ethyl)carbostyril hydrochloride

Biological Activity

[Description]:

Carmoterol hydrochloride is a highly potent, selective and long-acting β2-adrenoceptor agonist with the pEC50 of 10.19. Carmoterol has 53 times higher affinity for the β2-adrenoceptors than for the β1-adrenoceptors. Carmoterol hydrochloride can be used for the research of asthma and chronic obstructive pulmonary disease (COPD)[1][2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor
Research Areas >> Inflammation/Immunology

[References]

[1]. Mario Cazzola, et al. β(2) -adrenoceptor agonists: current and future direction. Br J Pharmacol. 2011 May;163(1):4-17.  

[2]. Giuseppe Rossoni, et al. Positive interaction of the novel beta2-agonist carmoterol and tiotropium bromide in the control of airway changes induced by different challenges in guinea-pigs. Pulm Pharmacol Ther. 2007;20(3):250-7.  

Chemical & Physical Properties

[ Boiling Point ]:
649.1ºC at 760mmHg

[ Molecular Formula ]:
C21H25ClN2O4

[ Molecular Weight ]:
404.887

[ Flash Point ]:
346.4ºC

[ Exact Mass ]:
404.150299

[ PSA ]:
94.58000

[ LogP ]:
3.68940

Related Compounds