LY3027788

Names

[ Name ]:
LY3027788

Biological Activity

[Description]:

A orally active prodrug of LY3020371, which is a potent, selective metabotropic glutamate 2/3 receptor (mGlu2/3) antagonist with Ki of 5.3 and 2.5 nM, respectively; augments the antidepressant-like effects of fluoxetine or citalopram without altering plasma or brain levels of these compounds.

[References]

References 1. Witkin JM, et al. J Pharmacol Exp Ther. 2017 Apr;361(1):68-86. View Related Products by Target mGluR

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₅H₃₁F₂NO₁₁S

[ Molecular Weight ]:
591.576

Related Compounds

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