BRD9539

Names

[ Name ]:
BRD9539

[Synonym ]:
1H-Benzimidazole-5-carboxylic acid, 2-[[(1E)-hydroxyphenylmethylene]amino]-1-(3-phenylpropyl)-
2-{(E)-[Hydroxy(phenyl)methylene]amino}-1-(3-phenylpropyl)-1H-benzimidazole-5-carboxylic acid
BRD9539

Biological Activity

[Description]:

BRD9539 inhibits G9a activity with an IC50 of 6.3 μM, inhibits PRC2 activity with a similar IC50.target: G9a, PRC2;IC50: 6.3 μM ( G9a ), 6.3 uM ( PRC2 ); BRD9539 is a more potent biochemical inhibitor than its methyl-ester analogue BRD4770, with 20% remaining G9a activity compared to 45% of BRD4770 at screening concentration.

[Related Catalog]:

Signaling Pathways >> Epigenetics >> Histone Methyltransferase

Research Areas >> Cancer

[References]

[1]. Yuan Y et al. A small-molecule probe of the histone methyltransferase G9a induces cellular senescence in pancreatic adenocarcinoma. ACS Chem Biol. 2012 Jul 20;7(7):1152-7.

[Related Small Molecules]

GSK126 | Tazemetostat (EPZ-6438) | UNC 0642 | GSK343 | Pinometostat (EPZ5676) | 3-Deazaneplanocin A (hydrochloride) | Pemrametostat (GSK3326595) | UNC1999 | BIX-01294 | EPZ031686 | AZ505 (ditrifluoroacetate) | MS023 | EPZ 004777 | EPZ015666 | EPZ015866(GSK591)

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
676.4±57.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₄H₂₁N₃O₃

[ Molecular Weight ]:
399.442

[ Flash Point ]:
362.9±32.1 °C

[ Exact Mass ]:
399.158295

[ LogP ]:
5.82

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.650

[ Storage condition ]:
2-8℃

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ RIDADR ]:
NONH for all modes of transport

Related Compounds

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