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R-Hydroxychloroquine

Names

[ CAS No. ]:
137433-23-9

[ Name ]:
R-Hydroxychloroquine

Biological Activity

[Description]:

(R)-Hydroxychloroquine is the enantiomer of Hydroxychloroquine[1]. Hydroxychloroquine is a synthetic antimalarial drug which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine is efficiently inhibits SARS-CoV-2 infection in vitro[2][3][4].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR)
Research Areas >> Infection
Signaling Pathways >> Anti-infection >> SARS-CoV
Signaling Pathways >> Autophagy >> Autophagy

[References]

[1]. Cardoso CD, et al. Enantioselective analysis of the metabolites of hydroxychloroquine and application to an in vitro metabolic study. J Pharm Biomed Anal. 2005 Apr 1;37(4):703-8.

[2]. Manzo C, et al. Psychomotor Agitation Following Treatment with Hydroxychloroquine. Drug Saf Case Rep. 2017 Dec;4(1):6.

[3]. . Lamphier M, et al. Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo. Mol Pharmacol. 2014 Mar;85(3):429-40.

Chemical & Physical Properties

[ Molecular Formula ]:
C18H26ClN3O

[ Molecular Weight ]:
335.87

Related Compounds