Otlertuzumab

Names

[ CAS No. ]:
1372645-37-8

[ Name ]:
Otlertuzumab

Biological Activity

[Description]:

Otlertuzumab (TRU-016) is a humanized anti-CD37 monoclonal antibody that can be used for cancer research[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[Target]

CD37[1]

[In Vitro]

Otlertuzumab (TRU-016) in combination with Rituximab (HY-P9913), Rapamycin (HY-10219), or Bendamustine (HY-13567) increases cell killing of NHL cells[2]. Otlertuzumab has the ability to bind to and kill CD37+ cells[3].

[In Vivo]

Otlertuzumab (TRU-016) in combination with Bendamustine (HY-13567) displays greater anti-tumor activity than either agent alone against a follicular lymphoma tumor model in SCID mice[2]. Otlertuzumab shows significant antitumor activity in mice bearing Ramos or Daudi tumor xenografts[3].

Chemical & Physical Properties

No Any Chemical & Physical Properties