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Fibrinogen-Binding Peptide

Names

[ CAS No. ]:
137235-80-4

[ Name ]:
Fibrinogen-Binding Peptide

[Synonym ]:
(4S)-4-amino-5-[[(2S)-1-[[(2S,3S)-1-[(2S)-2-[[(2S)-1-hydroxy-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxopentan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
Glutamyl-histidyl-isoleucyl-prolyl-alanine
Glu-his-ile-pro-ala

Biological Activity

[Description]:

Fibrinogen-Binding Peptide (designed by anticomplementarity hypothesis) is a presumptive peptide mimic of the vitronectin binding site on the fibrinogen receptor. Fibrinogen-Binding Peptide binds fibrinogen and inhibits both the adhesion of platelets to fibrinogen and platelet aggregation, and also inhibits the adhesion of platelets to vitronectin[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> Others >> Others

[References]

[1]. Gartner TK, et al. The peptide Glu-His-Ile-Pro-Ala binds fibrinogen and inhibits platelet aggregation and adhesion to fibrinogen and vitronectin. Proc Soc Exp Biol Med. 1991 Oct;198(1):649-55.

Chemical & Physical Properties

[ Density]:
1.343 g/cm3

[ Boiling Point ]:
1067.8ºC at 760 mmHg

[ Molecular Formula ]:
C25H39N7O8

[ Molecular Weight ]:
565.62

[ Flash Point ]:
599.6ºC

[ Exact Mass ]:
565.28600

[ PSA ]:
236.91000

[ LogP ]:
0.55120

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.577

Related Compounds