Lotilaner

Names

[ Name ]:
Lotilaner

Biological Activity

[Description]:

Lotilaner is a parasiticide, acts as a potent non-competitive antagonist of insects GABACl receptors, with an IC50 of 23.84 nM for Drosophila melanogaster GABA receptor. No effect on a dog GABAA receptor[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Parasite

Research Areas >> Infection

Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor

Signaling Pathways >> Neuronal Signaling >> GABA Receptor

[Target]

IC50: 23.84 nM (DmS-GABA), 38.25 nM (DmR2-GABA), 52.40 nM (Ls-GABA1), 36.79 nM (Rm-GABA)[1]

[In Vitro]

Lotilaner shows IC50s of 38.25 ± 3.75, 52.40 ± 4.54, 36.79 ± 4.39 nM for Drosophila melanogaster dieldrin/fipronil-resistant forms (DmR2), Lepeophtheirus salmonis (Ls) and Rhipicephalus microplus (Rm) GABACl receptors, respectively[1].

[References]

[1]. Lotilaner, et al. The novel isoxazoline ectoparasiticide lotilaner (Credelio™): a non-competitive antagonist specific to invertebrates γ-aminobutyric acid-gated chloride channels (GABACls). Parasit Vectors. 2017 Nov 1;10(1):530.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₁₄Cl₃F₆N₃O₃S

[ Molecular Weight ]:
596.76

[ Exact Mass ]:
594.97300

[ PSA ]:
108.03000

[ LogP ]:
6.22460

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.