Boc-NH-PEG2-CH2CH2COOH

Names

[ Name ]:
Boc-NH-PEG2-CH2CH2COOH

[Synonym ]:
2,2-Dimethyl-4-oxo-3,8,11-trioxa-5-azatetradecan-14-oic acid
3,8,11-Trioxa-5-azatetradecan-14-oic acid, 2,2-dimethyl-4-oxo-
MFCD22056304
N-Boc-3-[2-(2-aminoethoxy)ethoxy]propionic Acid

Biological Activity

[Description]:

Boc-NH-PEG2-CH2CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTAC[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Alkyl/ether

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Li Y, et al. Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis TargetingChimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable TumorRegression. J Med Chem. 2019 Jan 24;62(2):448-466.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
429.9±35.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₂H₂₃NO₆

[ Molecular Weight ]:
277.314

[ Flash Point ]:
213.8±25.9 °C

[ Exact Mass ]:
277.152527

[ LogP ]:
0.57

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.465

Related Compounds

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