proTAME

Names

[ Name ]:
proTAME

[Synonym ]:
L-Ornithine, N5-[bis[[[[(2-phenylacetyl)oxy]methoxy]carbonyl]amino]methylene]-N2-[(4-methylphenyl)sulfonyl]-, methyl ester
Methyl N2-[(4-methylphenyl)sulfonyl]-N5-(2,6,10,14-tetraoxo-1,15-diphenyl-3,5,11,13-tetraoxa-7,9-diazapentadecan-8-ylidene)-L-ornithinate

Biological Activity

[Description]:

proTAME is a cell permeable prodrug of TAME, which is an anaphase-promoting complex/cyclosome (APC/C) inhibitor that binds to the APC preferentially suppresses APC/C(Cdc20); arrests cells in metaphase without perturbing the spindle, but is dependent on the spindle assembly checkpoint (SAC); efficiently targets osteosarcoma in vitro combined with chemotherapeutic agents.

[References]

References 1. Zeng X, et al. Cancer Cell. 2010 Oct 19;18(4):382-95. 2. Giovinazzi S, et al. Cell Cycle. 2013 Aug 15;12(16):2598-607. 3. Hu K, et al. Oncotarget. 2014 May 30;5(10):3088-100. View Related Products by Target E3 Ubiquitin Ligase

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Molecular Formula ]:
C₃₄H₃₈N₄O₁₂S

[ Molecular Weight ]:
726.750

[ Exact Mass ]:
726.220703

[ LogP ]:
6.05

[ Index of Refraction ]:
1.587

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.