FAAH-IN-2

A potent, selective, noncovalent FAAH inhibitor with IC50 of 28 nM toward human FAAH and 100 nM toward rat FAAH; demonstrates an excellent selectivity profile against a panel of cannabinoid related targets, including CB1, CB2, and VR1; demonstrates a unique nonmechanism-based inhibition of FAAH activity, which is distinct from almost all known FAAH inhibitors; shows excellent PK properties with a low clearance of 0.4 L/h/Kg and a high bioavailability of 92%.

References 1. Min X, et al. Proc Natl Acad Sci U S A. 2011 May 3;108(18):7379-84. View Related Products by Target FAAH