Necrosulfonamide

Names

[ Name ]:
Necrosulfonamide

[Synonym ]:
(E)-N-(4-(N-(3-methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophene-2-yl)acrylamide
(2E)-N-{4-[(3-Methoxy-2-pyrazinyl)sulfamoyl]phenyl}-3-(5-nitro-2-thienyl)acrylamide
2-Propenamide, N-[4-[[(3-methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-, (2E)-
necrosulfonamide
CHEBI:63770
(2E)-N-{4-[(3-methoxypyrazin-2-yl)sulfamoyl]phenyl}-3-(5-nitrothiophen-2-yl)prop-2-enamide

Biological Activity

[Description]:

Necrosulfonamide is a necroptosis inhibitor acting by selectively targeting the mixed lineage kinase domain-like protein (MLKL) to block the necrosome formation.

[Related Catalog]:

Signaling Pathways >> MAPK/ERK Pathway >> Mixed Lineage Kinase

Research Areas >> Cancer

[References]

[1]. Steinhart L et al. Smac mimetic and demethylating agents synergistically trigger cell death in acute myeloid leukemia cells andovercome apoptosis resistance by inducing necroptosis. Cell Death Dis. 2013 Sep 12;

[2]. Sun L et al. Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell. 2012 Jan 20;148(1-2):213-27.

[3]. Dunai ZA et al. Staurosporine induces necroptotic cell death under caspase-compromised conditions in U937 cells. PLoS One. 2012;7(7):

[4]. Bae JH et al. Chemical regulation of signaling pathways to programmed necrosis. Arch Pharm Res. 2014 Jun;37(6):689-97.

[Related Small Molecules]

URMC-099 | TC13172

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Melting Point ]:
257 °C(dec.)

[ Molecular Formula ]:
C₁₈H₁₅N₅O₆S₂

[ Molecular Weight ]:
461.472

[ Exact Mass ]:
461.046387

[ LogP ]:
4.08

[ Index of Refraction ]:
1.695

Related Compounds

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