XZH-5

XZH-5 is a small moelcule that inhibits constitutive and interleukin-6-induced STAT3 phosphorylation, inhibits STAT3 DNA binding ability and downregulation of STAT3 downstream genes; inhibits downregulation of STAT3 downstream genes, such as Bcl-2, Bcl-xL, Cyclin D1 and Survivin, demonstrates blockade of STAT3 phosphorylation in human rhabdomyosarcoma cells with apoptosis and suppresses colony-forming ability and cell migration; blocks IL-6-induced STAT3 phosphorylation and nuclear translocation but not the stimulation of STAT1 phosphorylation by IFN-γ.

References 1. Liu Y, et al. Apoptosis. 2011 May;16(5):502-10. 2. Liu A, et al. Cancer Sci. 2011 Jul;102(7):1381-7. 3. Liu A, PLoS One. 2012;7(10):e46624. 4. Daka P, et al. Bioorg Med Chem. 2015 Mar 15;23(6):1348-55. View Related Products by Target STAT