LabMol-301

LabMol-301 inhibits both NS5 RdRp and NS2B-NS3pro activity (IC50: 0.8 and 7.4 μM, respectively). LabMol-301 has a cytoprotective effect and prevents Zika virus (ZIKV)-induced cell death[1].

Research Areas >> Infection

NS5 RdRp, NS2B-NS3pro[1]

LabMol-301 (20 μM) shows 99% inhibition rate of NS5 RdRp activity[1]. LabMol-301 (10 μM) inhibits more than 80% of the NS2B-NS3pro protease activity[1]. LabMol-301 interacts with ZIKV NS2B-NS3pro at the allosteric site relied on a highly hydrophobic complementarity between the molecule’s surfaces and the protein[1]. LabMol-301 is able to protect GSC387 cell from cell death induced by ZIKV (EC50: 6.68 μM)[1].