Methylamino-PEG3-azide

Names

[ Name ]:
Methylamino-PEG3-azide

[Synonym ]:
2-{2-[2-(2-Azidoethoxy)ethoxy]ethoxy}-N-methylethanamine
Ethanamine, 2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]-N-methyl-
MFCD29042356

Biological Activity

[Description]:

Methylamino-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C₉H₂₀N₄O₃

[ Molecular Weight ]:
232.280

[ Exact Mass ]:
232.153534

[ LogP ]:
-0.78

Related Compounds

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