Bullatine A

Names

[ Name ]:
Bullatine A

[Synonym ]:
21-Ethyl-4-methyl-7,20-cycloatid-16-ene-11,15-diol

Biological Activity

[Description]:

Bullatine A (BLA), a diterpenoid alkaloid of the genus Aconitum, possesses anti-rheumatic, anti-inflammatory and anti-nociceptive effects. Bullatine A (BLA) is a potent P2X7 antagonist, inhibits ATP-induced cell death/apoptosis and P2X receptor-mediated inflammatory responses[1].Bullatine A attenuates pain hypersensitivity, regardless of the pain models employed[2].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Membrane Transporter/Ion Channel >> P2X Receptor

[References]

[1]. Li J, et al. Bullatine A, a diterpenoid alkaloid of the genus Aconitum, could attenuate ATP-induced BV-2 microglia death/apoptosis via P2X receptor pathways. Brain Res Bull. 2013 Aug;97:81-5.

[2]. Huang Q, et al. Bullatine A stimulates spinal microglial dynorphin A expression to produce anti-hypersensitivity in a variety of rat pain models. J Neuroinflammation. 2016 Aug 30;13(1):214.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
488.2±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₂H₃₃NO₂

[ Molecular Weight ]:
343.503

[ Flash Point ]:
242.3±27.4 °C

[ Exact Mass ]:
343.251129

[ PSA ]:
43.70000

[ LogP ]:
3.07

[ Vapour Pressure ]:
0.0±2.8 mmHg at 25°C

[ Index of Refraction ]:
1.620

Safety Information

[ HS Code ]:
29339900

Related Compounds

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