EW-7195

Names

[ Name ]:
EW-7195

Biological Activity

[Description]:

A novel potent and selective TGF-βRI (ALK5) inhibitor with IC50 of 4.83 nM, dispalys >300-fold selectivity over p38α; decreases phosphorylated Smad2 levels and the nuclear translocation of Smad2 increased by TGF-β1, inhibits TGF-β1-induced epithelial-to-mesenchymal transition (EMT) and wound healing of NMuMG cells; inhibits metastasis to lung from breast tumours in xenografted mice.

[References]

References 1. Park CY, et al. Eur J Cancer. 2011 Nov;47(17):2642-53. View Related Products by Target TGF beta Receptor (TGFBR)

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₁₈N₈

[ Molecular Weight ]:
406.453

Related Compounds

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