5WKS

Names

[ Name ]:
5WKS

[Synonym ]:
2-Chloro-N-(1-isopropyl-4-piperidinyl)-6-methoxy-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine
4-Quinazolinamine, 2-chloro-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-

Biological Activity

[Description]:

G9a-IN-1 (Compound 113) is a G9a protein inhibitor. G9A/EHMT2 is a nuclear histone lysine methyltransferase that catalyzes histone H3 lysine 9 dimethylation (H3K9me2), which is a reversible modification generally associated with transcriptional gene silencing. G9a-IN-1 can be used for the research of autoimmune disorders or cancer[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Epigenetics >> Histone Methyltransferase

Research Areas >> Inflammation/Immunology

[References]

[1]. Dimitrios Iliopoulos, et al. Small molecules for the treatment of autoimmune diseases and cancer. WO2022031939A1

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
529.3±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₄H₃₆ClN₅O₂

[ Molecular Weight ]:
462.028

[ Flash Point ]:
273.9±30.1 °C

[ Exact Mass ]:
461.255768

[ LogP ]:
4.89

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.600

Related Compounds

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