8-amino-3,6-dioxaoctanoic acid

Names

[ Name ]:
8-amino-3,6-dioxaoctanoic acid

[Synonym ]:
Acetic acid,2-[2-(2-aminoethoxy)ethoxy]
(2-aminoethoxy)ethoxyacetic acid
8-Amino-3,6-dioxaoctanoic acid
2-(2-(2-Aminoethoxy)ethoxy)acetic acid
[2-(2-Aminoethoxy)ethoxy]acetic acid
Acetic acid, 2-[2-(2-aminoethoxy)ethoxy]-
[2-(N-2-amino ethoxy)ethoxy] acetic acid
ADOA
AEEA

Biological Activity

[Description]:

H2N-PEG2-CH2COOH belongs to a polyethylene glycol (PEG) linker covalently bound to E3 Ligase binding group (E3LB) and protein binding group (PB)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[References]

[1]. Thomas Pillow, et al. Protac antibody conjugates and methods of use. WO2017201449A1.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
323.8±22.0 °C at 760 mmHg

[ Melting Point ]:
124.0 to 128.0 °C

[ Molecular Formula ]:
C₆H₁₃NO₄

[ Molecular Weight ]:
163.17

[ Flash Point ]:
149.6±22.3 °C

[ Exact Mass ]:
163.084457

[ PSA ]:
81.78000

[ LogP ]:
-1.59

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.467

[ Storage condition ]:
-20°C

Safety Information

[ HS Code ]:
2922509090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922509090

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%