Thr-Asp-F-amidine

Names

[ Name ]:
Thr-Asp-F-amidine

[Synonym ]:
L-Ornithinamide, N-acetyl-L-threonyl-L-α-aspartyl-N5-(2-fluoro-1-iminoethyl)-
N-Acetyl-L-threonyl-L-α-aspartyl-N5-(2-fluoroethanimidoyl)-L-ornithinamide

Biological Activity

[Description]:

Thr-Asp-F-amidine (TDFA) is a highly potent, selective PAD4 (protein arginine deiminase 4) inhibitor with IC50 of 2.3 uM, displays ≥15-fold selectivity for PAD4 versus PAD1 and ≥50-fold versus PADs 2 and 3; active in cells and can be used to inhibit PAD4 activity in cellulo.

[References]

References 1. Jones JE, et al. ACS Chem Biol. 2012 Jan 20;7(1):160-5. View Related Products by Target Protein Arginine Deiminase (PAD)

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Molecular Formula ]:
C₁₇H₂₉FN₆O₇

[ Molecular Weight ]:
448.447

[ Exact Mass ]:
448.208160

[ LogP ]:
-2.92

[ Index of Refraction ]:
1.597

Related Compounds

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