RKI-1313

Names

[ Name ]:
RKI-1313

[Synonym ]:
1-(3-Methoxybenzyl)-3-[4-(pyridin-4-yl)thiazol-2-yl]urea
1-(3-Methoxybenzyl)-3-[4-(4-pyridinyl)-1,3-thiazol-2-yl]urea
Urea, N-[(3-methoxyphenyl)methyl]-N'-[4-(4-pyridinyl)-2-thiazolyl]-
RKI-1313

Biological Activity

[Description]:

RKI-1313 is a ROCK inhibitor with IC50s of 34, 8 µM for ROCK 1 and ROCK 2, respectively. RKI-1313 shows little effect on the phosphorylation levels of ROCK substrates, migration, invasion or anchorage-independent growth[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> ROCK

Signaling Pathways >> Stem Cell/Wnt >> ROCK

Signaling Pathways >> TGF-beta/Smad >> ROCK

[Target]

ROCK1:34 μM (IC50)

ROCK2:8 μM (IC50)

[References]

[1]. Patel RA, et al. RKI-1447 is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer. Cancer Res. 2012 Oct 1;72(19):5025-34.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Molecular Formula ]:
C₁₇H₁₆N₄O₂S

[ Molecular Weight ]:
340.400

[ Exact Mass ]:
340.099396

[ PSA ]:
104.38000

[ LogP ]:
2.08

[ Index of Refraction ]:
1.655

[ Storage condition ]:
-20℃

Precursor & DownStream

Precursor

DownStream

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.