BMS-903452

Names

[ Name ]:
BMS-903452

[Synonym ]:
49731B9ULN
BMS-903452
2(1H)-Pyridinone, 5-chloro-4-[[1-(5-chloro-2-pyrimidinyl)-4-piperidinyl]oxy]-1-[2-fluoro-4-(methylsulfonyl)phenyl]-
5-Chloro-4-{[1-(5-chloro-2-pyrimidinyl)-4-piperidinyl]oxy}-1-[2-fluoro-4-(methylsulfonyl)phenyl]-2(1H)-pyridinone

Biological Activity

[Description]:

BMS-903452 is a potent and selective GPR119 agonist for diabetes research[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> GPR119

Research Areas >> Metabolic Disease

[References]

[1]. Wacker DA, et al. Discovery of 5-chloro-4-((1-(5-chloropyrimidin-2-yl)piperidin-4-yl)oxy)-1-(2-fluoro-4-(methylsulfonyl)phenyl)pyridin-2(1H)-one (BMS-903452), an antidiabetic clinical candidate targeting GPR119. J Med Chem. 2014 Sep 25;57(18):7499-508.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
735.7±70.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₁H₁₉Cl₂FN₄O₄S

[ Molecular Weight ]:
513.369

[ Flash Point ]:
398.7±35.7 °C

[ Exact Mass ]:
512.048828

[ LogP ]:
2.19

[ Vapour Pressure ]:
0.0±2.4 mmHg at 25°C

[ Index of Refraction ]:
1.668

Related Compounds

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