NCGC00229600

Names

[ Name ]:
NCGC00229600

Biological Activity

[Description]:

NCGC00229600 is an allosteric inverse agonist of thyrotropin receptor (TSHR). NCGC00229600 inhibits both TSH and stimulating antibody activation of TSHRs endogenously expressed in Graves' disease[1].

[Related Catalog]:

Research Areas >> Endocrinology

Signaling Pathways >> GPCR/G Protein >> TSH Receptor

[References]

[1]. Neumann S, et al. A new small-molecule antagonist inhibits Graves' disease antibody activation of the TSH receptor. J Clin Endocrinol Metab. 2011 Feb;96(2):548-54.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₀H₂₉N₃O₃

[ Molecular Weight ]:
479.57

Related Compounds

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