ETHYLENE GLYCOL-BIS(BETA-AMINOETHYL ETHER)-N,N,N',N'-TETRAACETIC ACID TETRASODIUM SALT

Names

[ Name ]:
ETHYLENE GLYCOL-BIS(BETA-AMINOETHYL ETHER)-N,N,N',N'-TETRAACETIC ACID TETRASODIUM SALT

[Synonym ]:
tetrasodium,2-[2-[2-[2-[bis(carboxylatomethyl)amino]ethoxy]ethoxy]ethyl-(carboxylatomethyl)amino]acetate
Tetrasodium 3,12-bis(carboxylatomethyl)-6,9-dioxa-3,12-diazatetradecane-1,14-dioate
Ethylene glycol-bis(beta-aminoethyl ether)-N,N,N′,N′-tetraacetic acid tetrasodium salt

Biological Activity

[Description]:

EGTA tetrasodium is a specific calcium ion chelator. EGTA tetrasodium has an apparent calcium dissociation constant (Kd) of 60.5 nM at physiological pH (7.4) and has very high specificity for Ca2+ over Mg2+ (Mg2+ Kd 1-10 mM). EGTA tetrasodium significantly inhibits the substrate adherence capacity of inflammatory macrophages[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[In Vitro]

EGTA tetrasodium, proposed as endodontic irrigant, decreases substrate adherence capacity of inflammatory macrophages in a time- and dose-dependent manner. The EGTA tetrasodium concentration that causes an IC50 is 202 mM. Chelators react with calcium ions in the hydroxyapatite crystals to produce a metallic chelate. Removal of calcium ions from the dentine makes the dentinal tissue softer, especially the hydroxyapatite-rich peritubular dentin and increases the diameter of exposed dentinal tubules[2].

[References]

[1]. Harris RA, Hanrahan JW. Effects of EGTA on calcium signaling in airway epithelial cells. Am J Physiol. 1994;267(5 Pt 1):C1426-C1434. doi:10.1152/ajpcell.1994.267.5.C1426.

[2]. Segura-Egea JJ, Jiménez-Rubio A, Rios-Santos JV, Velasco-Ortega E, Calvo-Gutierrez JR. In vitro inhibitory effect of EGTA on macrophage adhesion: endodontic implications. J Endod. 2003;29(3):211-213.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₄H₂₀N₂Na₄O₁₀

[ Molecular Weight ]:
468.275

[ Exact Mass ]:
468.070862

[ PSA ]:
185.46000

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
22-24/25

[ RIDADR ]:
NONH for all modes of transport

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Related Compounds

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