Tyrphostin AG 835

Names

[ CAS No. ]:
133550-37-5

[ Name ]:
Tyrphostin AG 835

[Synonym ]:
AG 835
TYRPHOSTIN AG 835
Tyrphostin AG 835
TYRPHOSTIN B50

Biological Activity

[Description]:

(+)-Tyrphostin B44 (Tyrphostin AG 835) (Compound B50) is an EGRF inhibitor with antitumor activities[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> JAK/STAT Signaling >> EGFR

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR

[In Vitro]

(+)-Tyrphostin B44 (Tyrphostin AG 835) (Compound B50) (0-100 µM) inhibits cell survival with EC50 values of 3.12, 12.5 and 12.5 µM against CALO, INBL and HeLa cells, respectively[1].

[References]

[1]. Soto-Cruz I, et al. The tyrphostin B42 inhibits cell proliferation and HER-2 autophosphorylation in cervical carcinoma cell lines. Cancer Invest. 2008 Mar;26(2):136-44.

Chemical & Physical Properties

[ Density]:
1.299g/cm3

[ Boiling Point ]:
603ºC at 760mmHg

[ Melting Point ]:
146 °C

[ Molecular Formula ]:
C₁₈H₁₆N₂O₃

[ Molecular Weight ]:
308.33100

[ Flash Point ]:
318.5ºC

[ Exact Mass ]:
308.11600

[ PSA ]:
93.35000

[ LogP ]:
3.27308

[ Vapour Pressure ]:
3.9E-15mmHg at 25°C

[ Index of Refraction ]:
1.66

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
S22

[ RIDADR ]:
NONH for all modes of transport

Related Compounds

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