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MK-8325 dihydrochloride

Names

[ CAS No. ]:
1334314-19-0

[ Name ]:
MK-8325 dihydrochloride

[Synonym ]:
Carbamic acid, N-[(1S)-1-[[(2S)-4,4-difluoro-2-[4-[4-[2-[(5R)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methyl-1-oxobutyl]-3,3-dimethyl-1-aza-3-silacyclopent-5-yl]-1H-naphth[1,2-d]imidazol-7-yl]phenyl]-1H-imidazol-2-yl]-1-pyrrolidinyl]carbonyl]-2-methylpropyl]-, methyl ester, hydrochloride (1:2)
Methyl [(2S)-1-{(5R)-5-[7-(4-{2-[(2S)-4,4-difluoro-1-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-2-pyrrolidinyl]-1H-imidazol-4-yl}phenyl)-1H-naphtho[1,2-d]imidazol-2-yl]-3,3-dimethyl-1,3-azasilolidin-1-yl}-3-methyl-1-oxo-2-butanyl]carbamate dihydrochloride

Biological Activity

[Description]:

MK-8325 is a potent, selective pan-genotype HCV NS5A inhibitor with IC50 of 15, 1 and 3 pM for GT1a, GT1b and GT2a, respectively; also demonstrates potencies comparable to MK-4882 against a panel of mutants in both the GT1a and GT1b backgrounds (GT1a M28V IC50=0.1 nM); demonstrates no cell toxicity with a CC50 >25 uM against Huh-7 replicon cells. HCV Infection Phase 1 Clinical

[References]

References 1. Nair AG, et al. Bioorg Med Chem Lett. 2018 Mar 20. pii: S0960-894X(18)30242-7. View Related Products by Target HCV HCV Infection

Chemical & Physical Properties

[ Molecular Formula ]:
C43H54Cl2F2N8O6Si

[ Molecular Weight ]:
915.927

[ Exact Mass ]:
914.328064

Related Compounds