Bis-PEG7-PFP ester

Names

[ Name ]:
Bis-PEG7-PFP ester

[Synonym ]:
4,7,10,13,16,19,22-Heptaoxapentacosane-1,25-dioic acid, bis(2,3,4,5,6-pentafluorophenyl) ester
Bis(pentafluorophenyl) 4,7,10,13,16,19,22-heptaoxapentacosane-1,25-dioate

Biological Activity

[Description]:

Bis-PEG7-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
664.2±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₀H₃₂F₁₀O₁₁

[ Molecular Weight ]:
758.552

[ Flash Point ]:
342.1±26.4 °C

[ Exact Mass ]:
758.178467

[ LogP ]:
2.84

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.465

Bis-PEG7-PFP ester

Names

Biological Activity

Chemical & Physical Properties

Related Compounds