JNJ-42314415

Names

[ Name ]:
JNJ-42314415

[Synonym ]:
Imidazo[1,2-a]pyrazine, 3-[6-(2-methoxyethyl)-3-pyridinyl]-2-methyl-8-(4-morpholinyl)-
3-[6-(2-Methoxyethyl)-3-pyridinyl]-2-methyl-8-(4-morpholinyl)imidazo[1,2-a]pyrazine

Biological Activity

[Description]:

JNJ-42314415(JNJ42314415) is a potent, selective, centrally active phosphodiesterase 10A (PDE10A) inhibitor with Ki of 35 nM for human recombinant PDE10A; inhibits rPDE10A with Ki of 64 nM, >100-fold selectivity over the other 10 PDE families; blocks conditioned avoidance behavior and behaviors induced by nondopaminergic stimulants (phencyclidine, scopolamine) more efficiently than D(2) receptor blockers, with less pronounced catalepsy; shows antipsychotic activity with an improved side-effect profile in vivo.

[References]

References 1. Megens AA, et al. J Pharmacol Exp Ther. 2014 Apr;349(1):138-54. View Related Products by Target Phosphodiesterase (PDE)

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Molecular Formula ]:
C₁₉H₂₃N₅O₂

[ Molecular Weight ]:
353.418

[ Exact Mass ]:
353.185181

[ LogP ]:
0.82

[ Index of Refraction ]:
1.654

Related Compounds

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