Akt1&PKA-IN-2

Names

[ CAS No. ]:
1334108-00-7

[ Name ]:
Akt1&PKA-IN-2

Biological Activity

[Description]:

Akt1&PKA-IN-2 ((R)-29) is an inhibitor of PKB/AKT with cyclin-dependent kinase 2 (CDK2) selectivity. Akt1&PKA-IN-2 inhibits AKT1, PKAa and CDK2a with IC50 values of 0.007 µM, 0.01 µM and 0.69 µM, respectively[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PI3K/Akt/mTOR >> Akt
Signaling Pathways >> Cell Cycle/DNA Damage >> CDK

[Target]

Akt1:0.007 μM (IC50)

CDK2a:0.69 μM (IC50)


[References]

[1]. Ashton KS, et al. Design and synthesis of novel amide AKT1 inhibitors with selectivity over CDK2. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5191-6.  

Chemical & Physical Properties

[ Molecular Formula ]:
C20H17Cl2N3O

[ Molecular Weight ]:
386.27

Related Compounds

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