6-Bromohexylphosphonic acid

Names

[ CAS No. ]:
133345-66-1

[ Name ]:
6-Bromohexylphosphonic acid

[Synonym ]:
Phosphonic acid, (6-bromohexyl)-
MFCD25424118
(6-Bromohexyl)phosphonic acid

Biological Activity

[Description]:

6-Bromohexylphosphonic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl-Chain

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
374.1±44.0 °C at 760 mmHg

[ Molecular Formula ]:
C₆H₁₄BrO₃P

[ Molecular Weight ]:
245.051

[ Flash Point ]:
180.0±28.4 °C

[ Exact Mass ]:
243.986389

[ LogP ]:
0.50

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.506

Related Compounds

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