N-Desmethyl Apalutamide
Names
[ CAS No. ]:
1332391-11-3
[ Name ]:
N-Desmethyl Apalutamide
Biological Activity
[Description]:
N-Desmethyl Apalutamide is an active metabolite of Apalutamide. N-Desmethyl Apalutamide is a less potent antagonist of the androgen receptor and is responsible for one-third of the activity of Apalutamide. The formation of N-Desmethyl Apalutamide mediated predominantly by CYP2C8 and CYP3A4. N-Desmethyl Apalutamide is moderate to strong CYP3A4 and CYP2B6 inducer and has an excellent plasma-proteins bound concentration[1][2][3].
[Related Catalog]:
[Target]
CYP3A4 and CYP2B6[1];Androgen receptor[2]
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C20H13F4N5O2S
[ Molecular Weight ]:
463.41
[ Storage condition ]:
2-8°C