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Xipamide-d6

Names

[ CAS No. ]:
1330262-09-3

[ Name ]:
Xipamide-d6

[Synonym ]:
Diurex-d6
Lumitens-d6
Xipamide-d6
Aquaphor-d6
4-Chloro-5-sulfamoyl-2',6'-salicyloxylidide-d6
Chronexan-d6

Biological Activity

[Description]:

Xipamide-d6 is the deuterium labeled Xipamide. Xipamide is a sulfonamide-based diuretic. Xipamide is an antihypertensive agent able to selectively inhibit the anion exchanger (AE)[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> Others >> Others

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Prichard BN, et al. Xipamide. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy. Drugs. 1985 Oct;30(4):313-32.

[3]. Hannaert P, et al. Beneficial effects of xipamide on pH and Ca2+ ions of cardiac cells. Arch Mal Coeur Vaiss. 1990 Jul;83(8):1271-4.

Chemical & Physical Properties

[ Molecular Formula ]:
C15H9ClD6N2O4S

[ Molecular Weight ]:
360.84600

[ Exact Mass ]:
360.08200

[ PSA ]:
121.36000

[ LogP ]:
4.72720

Related Compounds