solasulfone
Names
[ CAS No. ]:
133-65-3
[ Name ]:
solasulfone
[Synonym ]:
EINECS 205-116-7
RP 3668
Solapsone
Cimedone
sulphetrone
sulfetrone
Chemical & Physical Properties
[ Molecular Formula ]:
C30H28N2Na4O14S5
[ Molecular Weight ]:
892.83200
[ Exact Mass ]:
891.97300
[ PSA ]:
328.90000
[ LogP ]:
7.98900
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TZ2580000
- CHEMICAL NAME :
- 1,3-Propanedisulfonic acid, 1,1'-(sulfonylbis(p-phenyleneimino))bis(3-phenyl-, tetrasodium salt
- CAS REGISTRY NUMBER :
- 133-65-3
- LAST UPDATED :
- 199512
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C30-H28-N2-O14-S5.4Na
- MOLECULAR WEIGHT :
- 892.86
- WISWESSER LINE NOTATION :
- WSO&YR&1YSWO&MR DSWR DMYSWO&1YR&SWO &-NA- 4
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 4 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 5,213,1955
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 4500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARTUA4 American Review of Tuberculosis. (New York, NY) V.1-70, 1917-54. For publisher information, see ARDSBL. Volume(issue)/page/year: 60,62,1949
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2700 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - cyanosis
- REFERENCE :
- BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 3,15,1948 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 48 mg/kg/40D-C
- TOXIC EFFECTS :
- Blood - microcytosis with or without anemia Related to Chronic Data - death
- REFERENCE :
- BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 3,15,1948