Cinnamyl-3,4-dihydroxy-α-cyanocinnamate

Names

[ Name ]:
Cinnamyl-3,4-dihydroxy-α-cyanocinnamate

Biological Activity

[Description]:

Cinnamyl-3,4-dihydroxy-α-cyanocinnamate (CDC) is a potent 12/15-Lipoxygenases (LO) inhibitor. Cinnamyl-3,4-dihydroxy-α-cyanocinnamate has the potential for the research of type 1 diabetes mellitus[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase

Research Areas >> Metabolic Disease

[In Vitro]

High glucose or 12(S)-HETE remarkably increased transendothelial dextran transport, and in combination it was increased further. Addition of the 12/15-LO inhibitor, CDC, partially suppressed dextran transport[1].

[In Vivo]

The high glucose and 12(S)-hydroxyeicosatetraenoic acid (HETE) could alter vascular endothelial (VE)-cadherin and β‐catenin phosphorylation levels, but did not alter total protein expression. However, the 12/15-LO inhibitor, Cinnamyl-3,4-dihydroxy-α-cyanocinnamate (CDC), antagonized the effect of high glucose on protein phosphorylation to mitigate destruction of the endothelial cell barrier, and the mouse diabetes mellitus model further confirmed these conclusions[1].

[References]

[1]. Wang X, et al. 12(S)-hydroxyeicosatetraenoic acid impairs vascular endothelial permeability by altering adherens junction phosphorylation levels and affecting the binding and dissociation of its components in high glucose-induced vascular injury. J Diabetes Investig. 2019;10(3):639-649.

Chemical & Physical Properties

[ Density]:
1.326 g/cm3

[ Boiling Point ]:
583.9ºC at 760 mmHg

[ Molecular Formula ]:
C₁₉H₁₅NO₄

[ Molecular Weight ]:
321.32700

[ Flash Point ]:
307ºC

[ Exact Mass ]:
321.10000

[ PSA ]:
90.55000

[ LogP ]:
3.26138

[ Storage condition ]:
-20°C

Safety Information

[ Symbol ]:

GHS07, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H317-H410

[ Precautionary Statements ]:
P273-P280-P501

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
43-50/53

[ Safety Phrases ]:
36/37-60-61

[ RIDADR ]:
UN 3077 9 / PGIII

Precursor & DownStream

Precursor

DownStream

Related Compounds

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