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UNC0646

Names

[ CAS No. ]:
1320288-17-2

[ Name ]:
UNC0646

[Synonym ]:
N-(1-cyclohexylpiperidin-4-yl)-2-(4-isopropyl-1,4-diazepan-1-yl)-6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinazolin-4-amine
Benzenemethanamine,N-(1-cyclohexylethylidene)
N-(1-cyclohexylethylidene)benzylamine
UNC0646

Biological Activity

[Description]:

UNC0646 is a potent and selective G9a inhibitor with IC50 of 6 nM.IC50 value: 6 nM [1]Target: G9aUNC0646 is a potent and selective inhibitor of the homologous protein lysine methyltransferases, G9a and GLP (IC50 values are 6 nM and 15 nM for G9a and GLP, respectively). UNC0646 potently blocks G9a/GLP methyltransferase activity in cells (IC50 = 10 nM in MCF7 cells); exhibits low cellular toxicity (EC50 = 4.7 μM in MCF7 cells). UNC0646 is selective for G9a/GLP over a range of other protein lysine methyltransferases and protein arginine methyltransferases.

[Related Catalog]:

Signaling Pathways >> Epigenetics >> Histone Methyltransferase
Research Areas >> Cancer

[References]

[1]. Liu F, et al. Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines. J Med Chem. 2011 Sep 8;54(17):6139-50.


[Related Small Molecules]

GSK126 | Tazemetostat (EPZ-6438) | UNC 0642 | GSK343 | Pinometostat (EPZ5676) | 3-Deazaneplanocin A (hydrochloride) | Pemrametostat (GSK3326595) | UNC1999 | BIX-01294 | EPZ031686 | AZ505 (ditrifluoroacetate) | MS023 | EPZ 004777 | EPZ015666 | EPZ015866(GSK591)

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
754.6±70.0 °C at 760 mmHg

[ Molecular Formula ]:
C36H59N7O2

[ Molecular Weight ]:
621.899

[ Flash Point ]:
410.1±35.7 °C

[ Exact Mass ]:
621.473022

[ PSA ]:
72.46000

[ LogP ]:
5.75

[ Vapour Pressure ]:
0.0±2.5 mmHg at 25°C

[ Index of Refraction ]:
1.587

[ Storage condition ]:
2-8℃

MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport


Related Compounds

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