Imigliptin dihydrochloride

Names

[ Name ]:
Imigliptin dihydrochloride

[Synonym ]:
2-({7-[(3R)-3-Amino-1-piperidinyl]-3,5-dimethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl}methyl)benzonitrile
Benzonitrile, 2-[[7-[(3R)-3-amino-1-piperidinyl]-2,3-dihydro-3,5-dimethyl-2-oxo-1H-imidazo[4,5-b]pyridin-1-yl]methyl]-
Imigliptin

Biological Activity

[Description]:

A novel potent, selective, orally available DPP-4 inhibitor with IC50 of 9 nM; displays no activity against DPP-8 and DPP-9 (IC50>100 uM); shows strong effects on db/db mice in lowing glucose level, reducing AUC of oral glucose tolerance, decreasing TG and HbA1c levels, and protecting beta-cell. Diabetes Phase 2 Clinical

[References]

References 1. Shu C, et al. ACS Med Chem Lett. 2014 Jun 16;5(8):921-6. 2. Liu D, et al. Eur J Pharm Sci. 2016 Jun 30;89:73-82. View Related Products by Target Dipeptidyl Peptidase (DPP) Diabetes

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
595.3±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₁H₂₆Cl₂N₆O

[ Molecular Weight ]:
376.455

[ Flash Point ]:
313.8±30.1 °C

[ Exact Mass ]:
376.201172

[ LogP ]:
1.33

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.685

Related Compounds

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