Radalbuvir

Names

[ Name ]:
Radalbuvir

[Synonym ]:
5-(3,3-Dimethyl-1-butyn-1-yl)-3-[(cis-4-hydroxy-4-{[(3S)-tetrahydro-3-furanyloxy]methyl}cyclohexyl){[(1R)-4-methyl-3-cyclohexen-1-yl]carbonyl}amino]-2-thiophenecarboxylic acid
radalbuvir
UNII-273K4V0SPC
2-Thiophenecarboxylic acid, 5-(3,3-dimethyl-1-butyn-1-yl)-3-[[cis-4-hydroxy-4-[[[(3S)-tetrahydro-3-furanyl]oxy]methyl]cyclohexyl][[(1R)-4-methyl-3-cyclohexen-1-yl]carbonyl]amino]-

Biological Activity

[Description]:

Radalbuvir (GS-9669) is a non-nucleoside inhibitor of nonstructural protein 5B (NS5B) RNA-dependent RNA polymerase (RdRp). Radalbuvir shows strong anti-HCV potency (GT1a intrinsic EC50 = 2.9 nM, GT1b EC50 = 6 nM)[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HCV

Research Areas >> Infection

[In Vitro]

Radalbuvir (GS-9669) shows high in vitro metabolic stability, long residence time in rats, and maintained high activity against the NS5B M423T mutation (GT1b M423T EC50 = 14 nM)[1].

[References]

[1]. Zhou Z, et al. Small molecule NS5B RdRp non-nucleoside inhibitors for the treatment of HCV infection: A medicinal chemistry perspective. Eur J Med Chem. 2022 Jul 8;240:114595.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
721.2±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₀H₄₁NO₆S

[ Molecular Weight ]:
543.715

[ Flash Point ]:
389.9±32.9 °C

[ Exact Mass ]:
543.265442

[ LogP ]:
4.17

[ Vapour Pressure ]:
0.0±2.4 mmHg at 25°C

[ Index of Refraction ]:
1.599

Related Compounds

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