AZD8529 mesylate

Names

[ Name ]:
AZD8529 mesylate

[Synonym ]:
1H-Isoindol-1-one, 2,3-dihydro-7-methyl-5-[3-(1-piperazinylmethyl)-1,2,4-oxadiazol-5-yl]-2-[[4-(trifluoromethoxy)phenyl]methyl]-, methanesulfonate (1:1)
7-Methyl-5-[3-(1-piperazinylmethyl)-1,2,4-oxadiazol-5-yl]-2-[4-(trifluoromethoxy)benzyl]-1-isoindolinone methanesulfonate (1:1)
Azd-8529 Mesylate

Biological Activity

[Description]:

AZD8529 is a novel potent, selective mGluR2 positive allosteric modulator with EC50 of 195 nM, does not produce any positive allosteric modulator responses for mGluR1 and 3-8 subtypes; potentiates agonist-induced activation of mGluR2 in the membrane-binding assay and in primate cortex, hippocampus and striatum; decreases nicotine self-administration at doses (0.3-3 mg/kg) in monkeys, also reduces nicotine priming- and cue-induced reinstatement of nicotine seeking, decreases nicotine-induced accumbens dopamine release in rats. Schizophrenia Phase 2 Discontinued

[References]

References 1. Justinova Z, et al. Biol Psychiatry. 2015 Oct 1;78(7):452-62. 2. Caprioli D, et al. Biol Psychiatry. 2015 Oct 1;78(7):463-73. 3. Li X, et al. Psychopharmacology (Berl). 2016 May;233(10):1801-14. 4. Augier E, et al. Neuropsychopharmacology. 2016 Nov;41(12):2932-2940. View Related Products by Target mGluR Schizophrenia

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₅H₂₈F₃N₅O₆S

[ Molecular Weight ]:
583.580

[ Exact Mass ]:
583.171265

Related Compounds

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