Afatinib-d6

Names

[ Name ]:
Afatinib-d6

[Synonym ]:
(S,E)-4-(bis(trideuteromethyl)amino)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)but-2-enamide

Biological Activity

[Description]:

Afatinib D6 (BIBW 2992 D6) is deuterium labeled Afatinib. Afatinib (BIBW 2992) is an irreversible EGFR family inhibitor[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[Target]

EGFR[1]

[References]

[1]. Li D, et al. BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models. Oncogene. 2008 Aug 7;27(34):4702-11.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₁₉D₆ClFN₅O₃

[ Molecular Weight ]:
491.97500

[ Exact Mass ]:
491.20100

[ PSA ]:
88.61000

[ LogP ]:
4.53590

[ Storage condition ]:
-20C

Related Compounds

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