MDL 27399

Names

[ CAS No. ]:
131374-22-6

[ Name ]:
MDL 27399

[Synonym ]:
Meo-succ-ala-ala-pro-phe-cooch3
Mdl 27,399

Biological Activity

[Description]:

MDL 27399 is an inhibitor of human neutrophil cathepsin G (Ki = 7 μM). MDL 27399 can be used for research of inflammatory diseases[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Signaling Pathways >> Metabolic Enzyme/Protease >> Cathepsin

[References]

[1]. N.S. Doherty, et al. Novel inhibitors of polymorphonuclear neutrophil (PMN) elastase and cathepsin G: Evaluation in vitro of their potential for the treatment of inflammatory connective tissue damage. International Journal of Immunopharmacology. Volume 12, Issue 7, 1990, Pages 787-795

Chemical & Physical Properties

[ Density]:
1.239g/cm3

[ Boiling Point ]:
840.6ºC at 760mmHg

[ Molecular Formula ]:
C26H36N4O8

[ Molecular Weight ]:
532.58600

[ Flash Point ]:
462.2ºC

[ Exact Mass ]:
532.25300

[ PSA ]:
170.68000

[ LogP ]:
2.29930

[ Vapour Pressure ]:
1.76E-28mmHg at 25°C

[ Index of Refraction ]:
1.539

Related Compounds

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