Scutebarbatine X

Names

[ Name ]:
Scutebarbatine X

[Synonym ]:
3-Pyridinecarboxylic acid, (1R,2S,3R,4S,4aS,8aR)-4-[(1S)-1-(acetyloxy)-2-(2,5-dihydro-4-hydroxy-5-oxo-3-furanyl)ethyl]-1,2,3,4,4a,5,6,8a-octahydro-3-hydroxy-3,4,8,8a-tetramethyl-1,2-naphthalenediyl ester
(1R,2S,3R,4S,4aS,8aR)-4-[(1S)-1-Acetoxy-2-(4-hydroxy-5-oxo-2,5-dihydro-3-furanyl)ethyl]-3-hydroxy-3,4,8,8a-tetramethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene-1,2-diyl dinicotinate

Biological Activity

[Description]:

Scutebarbatine X (Compound 2) is a neo-clerodane diterpenoids isolated from Scutellaria barbatae (Labiatae) and has anti-inflammatory properties[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[In Vitro]

Scutebarbatine X 以剂量依赖性方式显著降低 LPS 刺激的 BV2 细胞产生 NO，IC50 值为 27.4 μM[1]。 Scutebarbatine X (15, 30 μM;1 h) 剂量依赖性地降低 BV2 细胞中 iNOS 的表达[1]。 Scutebarbatine X (7.5, 15, 30 μM; 24 h) 不会降低 BV2 细胞的活力[1]。

[References]

[1]. Lee SR, et al. Constituents from Scutellaria barbata Inhibiting Nitric Oxide Production in LPS-Stimulated Microglial Cells. Chem Biodivers. 2017 Nov;14(11).

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
812.2±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₄H₃₈N₂O₁₀

[ Molecular Weight ]:
634.67

[ Flash Point ]:
445.0±34.3 °C

[ Exact Mass ]:
634.252625

[ PSA ]:
171.44000

[ LogP ]:
3.73

[ Vapour Pressure ]:
0.0±3.1 mmHg at 25°C

[ Index of Refraction ]:
1.614

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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