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SDZ WAG 994

Names

[ CAS No. ]:
130714-47-5

[ Name ]:
SDZ WAG 994

[Synonym ]:
N-Cyclohexyl-2'-O-methyladenosine
SDZWAG994

Biological Activity

[Description]:

SDZ-WAG994 (WAG-994) is a stable, long-acting, selective and orally active A1-adenosine receptor agonist with a KD of 23 nM. SDZ-WAG994 can be used for the research of atrial fibrillation[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor

[Target]

KD: 23 nM (A1-adenosine receptor)[1]


[References]

[1]. O Piot, et al. Effects of a selective A1-adenosine receptor agonist on heart rate and heart rate variability during permanent atrial fibrillation. Pacing Clin Electrophysiol. 1998 Nov;21(11 Pt 2):2459-64.  

[2]. Wagner H, et al. General pharmacology of SDZ WAG 994, a potent selective and orally active adenosine A1 receptor agonist. Drug development research, 1995, 34(3): 276-288.

[3]. Piot O, et al. Effects of a selective A1-adenosine receptor agonist on heart rate and heart rate variability during permanent atrial fibrillation. Pacing Clin Electrophysiol. 1998 Nov;21(11 Pt 2):2459-64.  

Chemical & Physical Properties

[ Density]:
1.59g/cm3

[ Boiling Point ]:
647.2ºC at 760mmHg

[ Molecular Formula ]:
C17H25N5O4

[ Molecular Weight ]:
363.41

[ Flash Point ]:
345.2ºC

[ Exact Mass ]:
363.19100

[ PSA ]:
114.55000

[ LogP ]:
0.90950

[ Vapour Pressure ]:
1.23E-17mmHg at 25°C

[ Index of Refraction ]:
1.729

Related Compounds